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Yeah, Tim, on DIAN, just reminded for everyone that this is dominantly inherited type of Alzheimer's. How would the approval or I guess the nod of etokimab impact how you're thinking about your pending Alzheimer's readouts and development strategies from here. We know that it's driven by mutations here and amyloid over production and has a relatively longer follow-up, but we'll just have to wait and see that data. Hi, thanks for taking my questions here. Thanks, Dave. We'd like to take questions from as many callers as possible, so we ask that you limit your questions to two per caller. Hi, thanks so much for taking my two questions, and both of them are Kevin's favorite topic. So the first one is on CNS penetrance of your GLP-1 and I have two parts on the first one. I just want to make sure I hear your take on the CNS penetrant of both Trulicity and tirzepatide. If you beloved this article and you would like to collect more info relating to buy viagra online generously visit the website. So with respect to CNS penetration of GLP-1s, you're right that these are large molecular weight molecules. So those factors weigh against it, there is other factors that weight for it.

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This concludes our prepared remarks and now I'll turn the call over to Kevin to moderate the Q&A. We expect the volume gains that we saw in Q4 to be sustainable between 2020 and 2025 as we mentioned on our guidance call. If you have any thoughts regarding wherever and how to use buy generic viagra, you can get in touch with us at our own website. Our worldwide prescription trends are strong and we are well positioned entering 2020 to continue our positive trajectory and deliver our 2020 financial guidance. And in the light of that we believe that we are extremely well positioned. However, in light of most recent regulatory actions with other JAK inhibitors, we are also realistic in terms of our expectations to get 4 milligram approved in the US in the near term. In terms of Olumiant, well, we don't comment on regulatory actions for specific brands. Q4 in terms of new to brand and we are confident that we will continue to grow in the rheumatology space where there are lot of opportunities for us. So we have confidence in continued growth space of dermatology.

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